- Title
- Aging reduces the high-frequency and short-term adaptation of the vestibulo-ocular reflex in mice
- Creator
- Khan, Serajul I.; Hübner, Patrick P.; Brichta, Alan M.; Smith, Doug W.; Migliaccio, Americo A.
- Relation
- NHMRC.1061752 http://purl.org/au-research/grants/nhmrc/1061752
- Relation
- Neurobiology of Aging Vol. 51, Issue March 2017, p. 122-131
- Publisher Link
- http://dx.doi.org/10.1016/j.neurobiolaging.2016.12.007
- Publisher
- Elsevier
- Resource Type
- journal article
- Date
- 2017
- Description
- Prevailing evidence indicates a relatively late life decline in human vestibulo-ocular reflex (VOR) function. Although mice are commonly used in mechanistic studies of vestibular function, it remains unclear whether aging produces a corresponding decline in VOR function in mice. We sought to determine how the baseline VOR and its short-term adaptation were affected by aging. We tested 8 young (3-month old) and 8 aged (30-month old–equivalent to a ∼80-year old human) C57BL/6 mice. We measured their VOR response to whole-body static tilts and during 0.1–10 Hz whole-body sinusoidal and transient rotations before and after VOR adaptation training. Our data revealed minimal differences in static counter-tilt response between young and aged mice, but a significant deficit in baseline VOR gain in aged mice during transient rotations. Moreover, aged mice had a significant decrease in short-term VOR adaptation, particularly for training that sought to decrease the VOR response.
- Subject
- vestibulo-ocular reflex; vestibular adaptation; vestibular plasticity; aged mice; C57BL/6J mice
- Identifier
- http://hdl.handle.net/1959.13/1352395
- Identifier
- uon:30876
- Identifier
- ISSN:0197-4580
- Language
- eng
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